Балл 10
Число соавторов публикации - 4
Целевой показатель госзадания:
Целевой показатель госзадания:
- Рецензируемые научные статьи в периодических журналах, индексируемых в WEB of Science (WoS) - Q2 - Формула: 20/корень квадратный из Nавторов = 20/корень квадратный из 4 (2) = 10
- Рецензируемые научные статьи в периодических журналах, индексируемых в SCOPUS - Q1 - Формула: 12/корень квадратный из Nавторов = 12/корень квадратный из 4 (2) = 6
КБПР (методика 2025 г.) = 7.5
Количество соавторов публикации - 4
Публикация в изданиях из Белого списка уровень: 1, K=20
Публикация в изданиях из Белого списка уровень: 1, K=20
-
Андреева А. Ю.: количество аффилиаций - 2, вклад в КБПР публикации:
формула: K/(Nсоавторов*Nаффил) = 20/(4*2) = 2.5 -
Челебиева Э. С.: количество аффилиаций - 1, вклад в КБПР публикации:
формула: K/(Nсоавторов*Nаффил) = 20/(4*1) = 5
Статья в периодическом издании
Effects of Stress Hormone Epinephrine and Activation of Protein Kinase A on the Osmotic Stability and Functional Parameters of Red Blood Cells From Marsh Frog
| DOI | https://doi.org/10.1002/jez.70044 |
|---|---|
| Язык | Английский |
| Журнал | Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology ISSN: 2471-5638; Онлайн ISSN: 2471-5646 |
| Год | 2025 |
| Выходные данные | |
| Авторы | |
| Даты |
Поступила в редакцию: 10.02.2025 После доработки: 05.09.2025 Принята к публикации: 06.10.2025 Опубликована онлайн: 03.11.2025 |
| Абстракт | General stress-response of vertebrates to fluctuations of environmental conditions are conservative, and includes rapid release of neurotransmitters into blood. In amphibians, physiological effects of catecholamines (CA) on red blood cell (RBC) functions have been studied fragmentally despite the presence of adrenoreceptors on RBC membranes. In the present work the influence of epinephrine on RBC stability to hypoosmotic stress as well as intracellular reactive oxygen species (ROS) production levels and mitochondrial membrane potential have been studied on RBCs of marsh frogs Pelophylax ridibundus (in vitro). Additionally, the involvement of cAMP/Adenylate cyclase/protein kinase A (cAMP/AC/PKA) pathway in regulation of these processes have been evaluated. We showed that increase of RBC stability to hypoosmotic shock is mediated by activation of β-adrenoreceptors and independent from cAMP/PKA pathway. Lysis of RBCs treated with epinephrine occurred at lower osmolarities compared to non-stimulated cells and changes in RBC membrane properties were rapid (after 5 min incubation) and stable (following 60 min incubation). Addition of epinephrine to RBC suspensions or activation of cAMP/AC/PKA pathway (forskolin and cBIMPS) was associated with a reduction of ROS concentration in cytoplasm and enhanced mitochondrial membrane potential. The results of the present work provide novel insights into the cellular mechanisms of adrenergic RBC stimulation and pathways involved into signal transduction within the context of environmental stress. Stimulating effects of epinephrine on RBC membrane stability and mitochondrial activity is probably important for adaptation of frogs to unfavorable habitat conditions, seasonal activity and other stress factors. Ключевые слова: catecholamines, marsh frog, mitochondrial membrane potential, osmotic stability, protein kinase A, reactive oxygen species, red blood cells |
| Сведения о финансировании, указанные в публикации | The study of epinephrine and cAMP/AC/PKA stimulation on the osmotic stability curve was supported by the State Assignment of Ministry of Science and Higher Education of the Russian Federation (project no. 075-00264-24-00 to A.A. Yu., M.I.V., G.S.). The study of effects of epinephrine and cAMP/AC/PKA stimulation on ROS levels and mitochondrial membrane potential in RBCs was funded by the State Assignment (“Mechanisms of functioning of bivalve immune system and the physiological basis of its adaptation to abiotic, biotic, and anthropogenic environmental factors” [No. 124030100090-4] to A.A. Yu., C.E.S). |
| URL | https://onlinelibrary.wiley.com/doi/10.1002/jez.70044 |
| Дополнительные сведения |
Запись создана: 10-11-2025 13:36
Последнее изменение: 21-01-2026 12:49
Библиографическая ссылка:
Andreyeva A. Yu., Chelebieva E. S., Mindukshev I. V., Gambaryan S. Effects of Stress Hormone Epinephrine and Activation of Protein Kinase A on the Osmotic Stability and Functional Parameters of Red Blood Cells From Marsh Frog // Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology. 2025. https://doi.org/10.1002/jez.70044 (Online first)
[WoS 1.400/Q2][SCOPUS 0.647/Q1][БС 1]
Andreyeva A. Yu., Chelebieva E. S., Mindukshev I. V., Gambaryan S. Effects of Stress Hormone Epinephrine and Activation of Protein Kinase A on the Osmotic Stability and Functional Parameters of Red Blood Cells From Marsh Frog // Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology. 2025. https://doi.org/10.1002/jez.70044 (Online first)
[WoS 1.400/Q2][SCOPUS 0.647/Q1][БС 1]
Экспертное заключение: № 396, 2025
Белый список
Индексация на момент включения в базу:- Уровень БС
- 1
Web of Science
- Статус
- Да
- Импакт-фактор/Квартиль(год)
- 1.400/Q2 (2024)
- Идентификатор
- 001606163200001
- Статус
- Да
- Импакт-фактор/Квартиль(год)
- 0.647/Q1 (2024)
- Идентификатор
- 2-s2.0-105020829134
В публикации указано госзадание:
№ 124030100090-4 «Механизмы функционирования иммунной системы двустворчатых моллюсков и физиологические основы ее адаптации к абиотическим, биотическим и антропогенным факторам окружающей среды»