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Дата внесения публикации в базу 28-02-2025 10:18 не попадает в период стимулирования 01-06-2025 – 31-05-2026
КБПР (методика 2025 г.) = 20
Количество соавторов публикации - 2
Публикация в изданиях из Белого списка уровень: 1, K=20
Публикация в изданиях из Белого списка уровень: 1, K=20
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Колесникова Е. Э.: количество аффилиаций - 1, вклад в КБПР публикации:
формула: K/(Nсоавторов*Nаффил) = 20/(2*1) = 10 -
Головина И. В.: количество аффилиаций - 1, вклад в КБПР публикации:
формула: K/(Nсоавторов*Nаффил) = 20/(2*1) = 10
Статья в периодическом издании
Effect of GABA mimetic phenibut on oxidoreductase activity in the brain compartments of adult and juvenile scorpionfish Scorpaena porcus Linnaeus, 1758
| DOI | https://doi.org/10.21072/mbj.2025.10.1.05 |
|---|---|
| Язык | Английский |
| Журнал | Морской биологический журнал ISSN: 2499-9768; Онлайн ISSN: – |
| Год | 2025 |
| Выходные данные | том: 10; номер: 1; страницы: 54-68 |
| Авторы | |
| Даты |
Поступила в редакцию: 23.05.2024 После доработки: 16.12.2024 Принята к публикации: 25.12.2024 Опубликована онлайн: 27.02.2025 |
| Абстракт | An increase in GABA levels serves to the survival of neurons during hypoxia/anoxia. During ontogenesis, GABA is capable of transforming its mediator function from excitatory to inhibitory. The oxidoreductase activity (MDH, 1.1.1.37; LDH, 1.1.1.27; and catalase, 1.11.1.6) was studied in the brain compartments – the medulla oblongata (MB) and the forebrain, diencephalon, and midbrain (AB) – in juvenile and adult black scorpionfish Scorpaena porcus against the backdrop of injection of GABA mimetic phenibut (400 mg·kg−1, i. p.). AB structures of juvenile scorpionfish were characterized by an intensity of aerobic metabolism comparable to that of adults. At the same time, an elevated LDH activity in juvenile MB and AB was observed which may serve to increased survivorship at low environmental PO2. Catalase activity in both age groups was somewhat higher in MB which may be related both to the intensity of oxidative phosphorylation and MB tolerance to injuries during hypoxia. Moreover, catalase activity in the brain of juveniles (especially in AB) was slightly lower than that of adults. Phenibut simultaneously increased MDH and LDH activity in the brain compartments of adult scorpionfish which may be associated with the activation of the malate-aspartate shuttle, with an opposite trend towards the restriction of anaerobic glycolysis in the juvenile brain being mostly pronounced in AB (p < 0.05). Simultaneously, phenibut contributed to a rise in catalase activity in all brain compartments, regardless of the age of scorpionfish (p < 0.05). Catalase activity was the highest in MB of adult individuals (p < 0.05). Apparently, catalase-controlled H2O2 level translates the changes in cellular metabolism into a meaningful physiological response by influencing H2O2-sensitive ion channels that determine neuronal excitability and modulates GABAergic transmission. Such a mechanism may be involved in the brain maturation, maintain brain resistance to hypoxia, and ensure adaptive processes in juvenile and adult scorpionfish. Ключевые слова: teleost fish, brain, phenibut, GABA receptors, oxidoreductases |
| Сведения о финансировании, указанные в публикации | This work was carried out within the framework of IBSS state research assignment “Functional, metabolic, and molecular genetic mechanisms of marine organism adaptation to conditions of extreme ecotopes of the Black Sea, the Sea of Azov, and other areas of the World Ocean” (No. 124030100137-6). |
| URL | https://marine-biology.ru/mbj/article/view/471 |
| Дополнительные сведения |
Запись создана: 28-02-2025 10:18
Последнее изменение: 14-04-2025 10:02
Библиографическая ссылка:
Kolesnikova E., Golovina I. Effect of GABA mimetic phenibut on oxidoreductase activity in the brain compartments of adult and juvenile scorpionfish Scorpaena porcus Linnaeus, 1758 // Морской биологический журнал. 2025. Т. 10, № 1. С. 54-68. https://doi.org/10.21072/mbj.2025.10.1.05
[SCOPUS 0.227/Q3][РИНЦ 0.845][БС 1]
Kolesnikova E., Golovina I. Effect of GABA mimetic phenibut on oxidoreductase activity in the brain compartments of adult and juvenile scorpionfish Scorpaena porcus Linnaeus, 1758 // Морской биологический журнал. 2025. Т. 10, № 1. С. 54-68. https://doi.org/10.21072/mbj.2025.10.1.05
[SCOPUS 0.227/Q3][РИНЦ 0.845][БС 1]
Экспертное заключение: № 456, 2024
Белый список
Индексация на момент включения в базу:- Уровень БС
- 1
Web of Science
- Статус
- Нет
- Статус
- Да
- Импакт-фактор/Квартиль(год)
- 0.227/Q3 (2023)
- Идентификатор
- 2-s2.0-105001850048
В публикации указано госзадание:
№ 124030100137-6 «Функциональные, метаболические и молекулярно-генетические механизмы адаптации морских организмов к условиям экстремальных экотопов Черного и Азовского морей и других акваторий Мирового океана»