Балл 0
Дата внесения публикации в базу 09-08-2021 12:52 не попадает в период стимулирования 01-06-2023 – 31-05-2024
КБПР (данная функция работает в тестовом режиме) 0.777
Количество соавторов публикации - 3
Публикации в изданиях, индексируемых в Web of Science Core Collection: без квартиля, K=1
Публикации в изданиях, индексируемых в Web of Science Core Collection: без квартиля, K=1
-
Бочарова Е. А.: количество аффилиаций - 1, вклад в КБПР публикации:
формула: K/(Nсоавторов*Nаффил) = 1/(3*1) = 0.333 -
Копытина Н. И.: количество аффилиаций - 1, вклад в КБПР публикации:
формула: K/(Nсоавторов*Nаффил) = 1/(3*1) = 0.333 -
Слынько Е. Е.: количество аффилиаций - 3, вклад в КБПР публикации:
формула: K/(Nсоавторов*Nаффил) = 1/(3*3) = 0.111
Статья в периодическом издании
Anti-tumour drugs of marine origin currently at various stages of clinical trials (review)
WoS –/–
| DOI | https://doi.org/10.15421/022136 |
|---|---|
| Язык | Английский |
| Журнал | Regulatory Mechanisms in Biosystems ISSN: 2519-8521; Онлайн ISSN: 2520-2588 |
| Год | 2021 |
| Выходные данные | Том: 12, Номер: 2, Страницы: 265-280 |
| Авторы | |
| Даты |
Поступила в редакцию: 19.04.2021 После доработки 12.05.2021 Принята к публикации: 14.05.2021 Опубликована: 14.05.2021 |
| Абстракт | Oncological diseases for a long time have remained one of the most significant health problems of modern society, which causes great losses in its labour and vital potential. Contemporary oncology still faces unsolved issues as insufficient efficacy of treatment of progressing and metastatic cancer, chemoresistance, and side-effects of the traditional therapy which lead to disabilities among or death of a high number of patients. Development of new anti-tumour preparations with a broad range of pharmaceutical properties and low toxicity is becoming increasingly relevant every year. The objective of the study was to provide a review of the recent data about anti-tumour preparations of marine origin currently being at various phases of clinical trials in order to present the biological value of marine organisms – producers of cytotoxic compounds, and the perspectives of their use in modern biomedical technologies. Unlike the synthetic oncological preparations, natural compounds are safer, have broader range of cytotoxic activity, can inhibit the processes of tumour development and metastasis, and at the same time have effects on several etiopathogenic links of carcinogenesis. Currently, practical oncology uses 12 anti-tumour preparations of marine origin (Fludarabine, Cytarabine, Midostaurin, Nelarabine, Eribulin mesylate, Brentuximab vedotin, Trabectedin, Plitidepsin, Enfortumab vedotin, Polatuzumab vedotin, Belantamab mafodotin, Lurbinectedin), 27 substances are at different stages of clinical trials. Contemporary approaches to the treatment of oncological diseases are based on targeted methods such as immune and genetic therapies, antibody-drug conjugates, nanoparticles of biopolymers, and metals. All those methods employ bioactive compounds of marine origin. Numerous literature data from recent years indicate heightened attention to the marine pharmacology and the high potential of marine organisms for the biomedicinal and pharmaceutic industries. Ключевые слова: cancer, marine organisms, preparations, cytotoxic preparations, clinical studies |
| Сведения о финансировании, указанные в публикации | |
| URL | https://medicine.dp.ua/index.php/med/article/view/717 |
| Дополнительные сведения |
Запись создана: 09-08-2021 12:52
Последнее изменение: 26-08-2021 10:40
Библиографическая ссылка:
Bocharova E. A., Kopytina N. I., Slynko Е. Е. Anti-tumour drugs of marine origin currently at various stages of clinical trials (review) // Regulatory Mechanisms in Biosystems. 2021. Vol. 12, no. 2. P. 265-280. https://doi.org/10.15421/022136
[WoS –/–]
Bocharova E. A., Kopytina N. I., Slynko Е. Е. Anti-tumour drugs of marine origin currently at various stages of clinical trials (review) // Regulatory Mechanisms in Biosystems. 2021. Vol. 12, no. 2. P. 265-280. https://doi.org/10.15421/022136
[WoS –/–]
Экспертное заключение: № 101, 2020
Индексация на момент включения в базу:
Web of Science
Web of Science
- Статус
- Да
- Импакт-фактор/Квартиль(год)
- –/– (–)
- Идентификатор
- 000684285300011
- Статус
- Нет
- Статус
- Нет
- ID
- 46397699
- EDN
- –
В публикации указано госзадание:
№ 121030300149-0 «Исследование механизмов управления продукционными процессами в биотехнологических комплексах с целью разработки научных основ получения биологически активных веществ и технических продуктов морского генезиса» (предыдущий номер АААА-А18-118021350003-6)